Journal of health research in community

Mendeley  

Zotero  

Rostamizadeh M, Khodaei K, Hamishehkar H. Effect of Combined Exercise Training with Gamma-Oryzanol Supplementation on Oxidative Stress, Total Antioxidant Capacity, Glycemic Parameters, and Insulin Resistance in Men With Type 2 Diabetes. , J Health Res Commun. 2026; 12 (2) :169-183
URL: http://jhc.mazums.ac.ir/article-1-1267-en.html

Introduction and Purpose: Chronic hyperglycemia in type 2 diabetes mellitus (T2DM) promotes oxidative stress by enhancing the production of reactive oxygen species (ROS) and impairing the endogenous antioxidant defense system. This study aimed to investigate the effects of eight weeks of combined exercise training, with and without gamma-oryzanol supplementation, on oxidative stress markers, total antioxidant capacity, glycemic indices, and insulin resistance in men with T2DM.
Methods: Thirty men with type 2 diabetes were purposively selected and divided into three groups (10 per group): combined exercise plus placebo, combined exercise plus supplementation, and placebo control. The exercise groups completed combined training for eight weeks, three sessions per week. The training consisted of resistance exercise at 40%–70% of 1RM and endurance exercise at 50%–70% of HRR. The supplement group consumed 600 mg of gamma-oryzanol daily in two doses for eight weeks. Fasting blood samples were collected 48 hours before and after the intervention to assess superoxide dismutase (SOD), malondialdehyde (MDA), total antioxidant capacity (TAC), insulin, and fasting blood glucose. Between-group differences were compared using a two-way repeated-measures analysis of variance and the LSD post hoc test, with a significance level of P≤0.05.
Results: Significant reductions were observed in FBG, insulin, HOMA-IR, HbA1c, and MDA levels in both intervention groups compared to the control group (P<0.05). Moreover, significant increases were found in SOD (P=0.012) and TAC (P=0.017) levels in the intervention groups versus the control group. However, the differences between the combined-exercise-plus-placebo group and the combined-exercise-plus-supplement group were not statistically significant (P>0.05). 
Conclusion: Eight weeks of combined (aerobic-resistance) training improved glycemic indices, insulin resistance, and oxidative stress in men with type 2 diabetes. This improvement was independent of gamma-oryzanol supplementation, as no additional effect was observed when this supplement was added to the training.